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Safety Concerns

Surely this article should have a section on the safety of THC as it is a major point of disagreement among experts that directly affects the FDA's consideration of THC as a drug candidate. Other pharmaceutical articles clearly have sections on safety and side effects, but this article appears to limit discussion of safety to toxicity. We wouldn't want to appear biased on the matter, as though safety were something to be overlooked, would we? — Preceding unsigned comment added by 50.54.219.172 (talk) 16:11, 29 April 2023 (UTC)[reply]

There is a fair bit of information addressing the safety concerns throughout the article. It is not collected in one place. It is also stated that very little research has been done to study this issue, and that its legal status in many countries prevents it from being studied for safety (short- or long-term) or efficacy for medical or other use. For now it's still a schedule I controlled substance in the US (i.e., unsafe for any human use), and the NIH hasn't been terribly friendly to research grant proposals that might contradict their administration's political position. (I suspect that will be changing, if it hasn't begun already.) However, there are sections in this article addressing toxicity, overdose, the WHO's position concerning its potential for dependency, and interaction with other drugs to the extent that such things are known. Dcs002 (talk) 00:38, 20 October 2023 (UTC)[reply]

Pharmacokinetics - absorption - sublingual or oral spray?

Does anybody have any sources for absorption, bioavailability, peak levels, and/or half-life if consumed as an oral spray or sublingually? These forms are available OTC or by prescription in many locations. The info should be out there, right? Thanks! Dcs002 (talk) 00:19, 20 October 2023 (UTC)[reply]

Synthesized and studied as early as 1942, fact keeps getting removed ==

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Delta-9-THC and Delta-8-THC was described, synthesized and studied as early as 1942 by Roger Adams but this fact keeps getting repeatedly removed. Roger Adams synthesized and studied THC over 20 years prior to Raphael Mechoulams study on Cannabis and THC.^[1]^[2]^[3] — Preceding unsigned comment added by Gettinglit (talk • contribs) 23:37, 16 January 2024 (UTC)[reply]

It was indeed researcher by Adams who identified CBD in 1940 but Adams and his teams did not identify it or focus on it, which only happenned when Gaoni and Mechoulam re-researched it. It's how science works, one can't just find it all or one sometimes has strong feelings but not yet solid grounds to prove anything… and sometimes 23 years need to pass before more solid information can be added by others. Teluobir (talk) 11:34, 30 August 2024 (UTC)[reply]

Also it was a mixture of the different isomers, if I am not mistaken, and the isolation of the isomer delta-9 (initially names delta-1) was indeed Gaoni and Mechoulam. Teluobir (talk) 11:57, 30 August 2024 (UTC)[reply]

References

Merge articles THC and Dronabinol.

Although many people have thought and continue to think Dronabinol is "synthetic THC"… it is not. It is just the INN for delta-9, and this is something that does not justify two articles. We don't have separate articles for the chemical name and the INN of the same molecult, generally. Worst, there are different bits of information and at times this article, at times the other, contain better or worst bits on specific topics. It would be really good to merge these articles (I think merging Dronabinol onto this one) taking the additional information and summing it up. This article would also deserve some update since I saw the information on WHO had not been actualised since 2003. Teluobir (talk) 11:45, 30 August 2024 (UTC)[reply]

"Dronabinolum" listed at Redirects for discussion

The redirect Dronabinolum has been listed at redirects for discussion to determine whether its use and function meets the redirect guidelines. Readers of this page are welcome to comment on this redirect at Wikipedia:Redirects for discussion/Log/2024 December 29 § Dronabinolum until a consensus is reached. 1234qwer 1234qwer 4 15:11, 29 December 2024 (UTC)[reply]

[1] ttps://patents.google.com/patent/US2419937A/en

[2] ttps://pubs.acs.org/doi/abs/10.1021/ja01255a061

[3] ttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1933888/

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[2]

[3]